JEE Main 2023 · 8 April · evening · Single correct · +4 / −1

The statement/s which are true about antagonists from the following is/are:
A. They bind to the receptor site.
B. Get transferred inside the cell for their action.
C. Inhibit the natural communication of the body.
D. Mimic the natural messenger.
Choose the correct answer from the options given below:

  1. (a) B only
  2. (b) A and B
  3. (c) A and C
  4. (d) A, C and D
Answer and solution

Answer (c) A and C

Solution

Chemistry ma’am · 3 steps

An antagonist sits in the receptor's lock but does not turn the key, so the message never gets through.

  1. What receptors do. A receptor is a protein in the cell membrane. A chemical messenger binds to it on the outside, and the receptor passes the message into the cell. The messenger itself does not enter the cell.
  2. Two kinds of drug. An agonist binds to the receptor and mimics the natural messenger, switching the receptor on. An antagonist binds to the same site but does not switch it on, so it blocks the messenger and inhibits the natural communication.
    StatementTrue for antagonists?Reason
    A. Bind to the receptor siteYesThey occupy the site the messenger would use
    B. Transferred inside the cellNoThey act at the receptor on the cell surface
    C. Inhibit natural communicationYesBlocking the site stops the message
    D. Mimic the natural messengerNoThat describes agonists
  3. So. Only A and C are true, which is option (c).

The idea to keep. Agonists and antagonists both bind to the receptor. Agonists mimic the messenger and switch the receptor on; antagonists block the site and switch the message off.

Answer from the NTA final answer key. Solution by PrepWiser.

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Asked about 60 times in JEE Main since 2020. This question is from 2023.