JEE Main 2020 · 5 September · morning · Single correct · +4 / −1

If a person is suffering from the deficiency of nor-adrenaline, what kind of drug can be suggested?

  1. (a) Anti-inflammatory
  2. (b) Antihistamine
  3. (c) Analgesic
  4. (d) Antidepressant
Answer and solution

Answer (d) Antidepressant

Solution

Chemistry ma’am · 3 steps

Low nor-adrenaline means low mood, so you need a drug that lifts mood: an antidepressant.

  1. What nor-adrenaline does. Nor-adrenaline is a neurotransmitter that helps control mood. When its level in the brain is low, signals that keep mood up get weaker, and the person becomes depressed.
  2. How the drug helps. Normally the enzyme that breaks down nor-adrenaline keeps its level in check. Antidepressants such as iproniazid and phenelzine block this enzyme, so nor-adrenaline lasts longer and the mood improves.
    Drug classWhat it treatsFixes low nor-adrenaline?
    Anti-inflammatorySwelling and inflammationNo
    AntihistamineAllergy, acidity (blocks histamine)No
    AnalgesicPainNo
    AntidepressantDepressionYes, it raises nor-adrenaline activity
  3. So. A person short of nor-adrenaline needs an antidepressant, option (d).

The idea to keep. Match the chemical messenger to the drug: low nor-adrenaline needs an antidepressant, while extra histamine needs an antihistamine.

Answer from the NTA final answer key. Solution by PrepWiser.

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Asked about 60 times in JEE Main since 2020. This question is from 2020.