JEE Main 2022 · 28 July · morning · Single correct · +4 / −1
Statements about Enzyme Inhibitor Drugs are given below :
(A) There are Competitive and Non-competitive inhibitor drugs.
(B) These can bind at the active sites and allosteric sites.
(C) Competitive Drugs are allosteric site blocking drugs.
(D) Non-competitive Drugs are active site blocking drugs.
Choose the correct answer from the options given below:
- (a) (A), (D) only
- (b) (A), (C) only
- (c) (A), (B) only
- (d) (A), (B), (C) only
Answer and solution
Answer (c) (A), (B) only
Solution
Chemistry ma’am · 3 steps
Match each inhibitor to its site: competitive sits in the active site, non-competitive at the allosteric site.
- Two kinds. Enzyme inhibitor drugs come in two kinds, competitive and non-competitive. Both kinds exist, so (A) is correct.
- Where they bind. A competitive inhibitor looks like the substrate and binds at the active site, so the two compete for the same spot. A non-competitive inhibitor binds at a different place, the allosteric site, and changes the shape of the active site so the substrate no longer fits.
Statement What it says Verdict (A) Competitive and non-competitive types exist Correct (B) They bind at active sites and allosteric sites Correct: competitive at the active site, non-competitive at the allosteric site (C) Competitive drugs block the allosteric site Wrong: they block the active site (D) Non-competitive drugs block the active site Wrong: they bind at the allosteric site - So. Only (A) and (B) are correct, which is option (c). Statements (C) and (D) have the two sites swapped.
The idea to keep. A competitive inhibitor competes with the substrate for the same active site. A non-competitive inhibitor does not compete: it binds at the allosteric site and distorts the active site.
Answer from the NTA final answer key. Solution by PrepWiser.