JEE Main 2022 · 28 July · morning · Single correct · +4 / −1

Statements about Enzyme Inhibitor Drugs are given below :
(A) There are Competitive and Non-competitive inhibitor drugs.
(B) These can bind at the active sites and allosteric sites.
(C) Competitive Drugs are allosteric site blocking drugs.
(D) Non-competitive Drugs are active site blocking drugs.
Choose the correct answer from the options given below:

  1. (a) (A), (D) only
  2. (b) (A), (C) only
  3. (c) (A), (B) only
  4. (d) (A), (B), (C) only
Answer and solution

Answer (c) (A), (B) only

Solution

Chemistry ma’am · 3 steps

Match each inhibitor to its site: competitive sits in the active site, non-competitive at the allosteric site.

  1. Two kinds. Enzyme inhibitor drugs come in two kinds, competitive and non-competitive. Both kinds exist, so (A) is correct.
  2. Where they bind. A competitive inhibitor looks like the substrate and binds at the active site, so the two compete for the same spot. A non-competitive inhibitor binds at a different place, the allosteric site, and changes the shape of the active site so the substrate no longer fits.
    StatementWhat it saysVerdict
    (A)Competitive and non-competitive types existCorrect
    (B)They bind at active sites and allosteric sitesCorrect: competitive at the active site, non-competitive at the allosteric site
    (C)Competitive drugs block the allosteric siteWrong: they block the active site
    (D)Non-competitive drugs block the active siteWrong: they bind at the allosteric site
  3. So. Only (A) and (B) are correct, which is option (c). Statements (C) and (D) have the two sites swapped.

The idea to keep. A competitive inhibitor competes with the substrate for the same active site. A non-competitive inhibitor does not compete: it binds at the allosteric site and distorts the active site.

Answer from the NTA final answer key. Solution by PrepWiser.

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Asked about 60 times in JEE Main since 2020. This question is from 2022.